Mass SpectrometryEndocrine Testing ItemsPlasma Catecholamines

Plasma Catecholamines

Abbreviation：BPCAMethod：Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS)

Product Overview
  • Analytes
    MN (Metanephrine)、NMN (Normetanephrine)、NE (Norepinephrine)、E (Epinephrine)、 DA (Dopamine)、and 3-MT (3-Methoxytyramine)
  • Clinical Applications (Examples)
    Accurate differential diagnosis of secondary hypertension caused by endocrine disorders such as pheochromocytoma and paraganglioma (PPGL), enabling timely treatment; provides diagnostic support for diseases associated with elevated catecholamine levels, including cardiovascular disease, cerebral infarction, and schizophrenia, as well as conditions associated with decreased catecholamine levels, such as Parkinson’s disease and malnutrition.
  • Sample Type
    Venous blood; store at -20°C or -80°C, protected from light.
  • Background

    Catecholamines are important signaling molecules involved in normal physiological processes, and changes in their plasma concentrations are closely associated with various pathological conditions. Elevated plasma catecholamine levels may cause episodic or sustained hypertension and are frequently accompanied by intermittent episodes of palpitations, arrhythmia, headache, sweating, pallor, anxiety, tremor, and nausea.
    Catecholamine secretion is intermittent, whereas their metabolites are released continuously. Therefore, plasma metanephrine (MN) and normetanephrine (NMN) are the preferred biomarkers for the diagnosis of pheochromocytoma and paraganglioma (PPGL). Patients with MN and NMN levels exceeding the upper reference limit by 3–4 times can be diagnosed with a high degree of confidence, while mildly elevated results can be further evaluated by measuring epinephrine (E), norepinephrine (NE), dopamine (DA), and 3-methoxytyramine (3-MT) for auxiliary diagnosis.

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  • Packing Specification
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